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Research Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study) BMJ 2012; 345 doi: 10.1136/bmj.e5339 (Published 29 August 2012) Cite this as: BMJ 2012;345:e5339 Degenerative joint disease Musculoskeletal syndromes Osteoarthritis Pain (neurology) More topics Immunology (including allergy) Clinical diagnostic tests Radiology Radiology (diagnostics) Calcium and bone Health education Health promotion Obesity (nutrition) Obesity (public health) Fewer topics Article Related content Article metrics Ali Guermazi, professor of radiology1, Jingbo Niu, research assistant professor of medicine2, Daichi Hayashi, research assistant professor of radiology1, Frank W Roemer, associate professor of radiology13, Martin Englund, associate professor, epidemiologist24, Tuhina Neogi, associate professor of medicine and epidemiology2, Piran Aliabadi, professor of radiology5, Christine E McLennan, project manager6, David T Felson, professor of medicine and epidemiology21Department of Radiology, Boston University School of Medicine, FGH Building, 820 Harrison Avenue, Boston, MA 02118, USA2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston3Klinikum Augsburg, Department of Radiology, Augsburg, Germany4Lund University, Clinical Sciences Lund, Department of Orthopaedics, Lund, Sweden5Brigham and Women’s Hospital, Harvard Medical School, Department of Radiology, Boston, MA 021156OptumInsight Life Sciences, Waltham, MA 02451Correspondence to: A Guermazi guermazi{at}bu.eduAccepted 23 July 2012AbstractObjective To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity.Design Population based observational study.Setting Community cohort in Framingham, MA, United States (Framingham osteoarthritis study).Participants 710 people aged >50 who had no radiographic evidence of knee osteoarthritis (Kellgren-Lawrence grade 0) and who underwent MRI of the knee.Main outcome measures Prevalence of MRI findings that are suggestive of knee osteoarthritis (osteophytes, cartilage damage, bone marrow lesions, subchondral cysts, meniscal lesions, synovitis, attrition, and ligamentous lesions) in all participants and after stratification by age, sex, body mass index (BMI), and the presence or absence of knee pain. Pain was assessed by three different questions and also by WOMAC questionnaire.Results Of the 710 participants, 393 (55%) were women, 660 (93%) were white, and 206 (29%) had knee pain in the past month. The mean age was 62.3 years and mean BMI was 27.9. Prevalence of “any abnormality” was 89% (631/710) overall. Osteophytes were the most common abnormality among all participants (74%, 524/710), followed by cartilage damage (69%, 492/710) and bone marrow lesions (52%, 371/710). The higher the age, the higher the prevalence of all types of abnormalities detectable by MRI. There were no significant differences in the prevalence of any of the features between BMI groups. The prevalence of at least one type of pathology (“any abnormality”) was high in both painful (90-97%, depending on pain definition) and painless (86-88%) knees.Conclusions MRI shows lesions in the tibiofemoral joint in most middle aged and elderly people in whom knee radiographs do not show any features of osteoarthritis, regardless of pain.IntroductionAgeing of the population and increasing obesity contribute to morbidity worldwide. Osteoarthritis is the most prevalent medically treated arthritic condition worldwide (for example, 3532 per 100?000 people in the United States).1 2 Diagnosis of osteoarthritis is made on the basis of clinical examination or radiography. Population based longitudinal studies in the US3 and the United Kingdom4 showed the lifetime risk of knee osteoarthritis increases with age,3 with the risk highest in obese people.3 4 Other prevalence surveys showed that radiographic osteoarthritis of the knee is common in middle aged and older adults.5 6Although many publications have reported structural changes in people with radiographic knee osteoarthritis, few data are available regarding what structural changes are present in knees without any radiographic features of osteoarthritis. About half of people with knee pain have no radiographic osteoarthritis. In clinical practice, it is unclear how to investigate and manage such people and whether additional imaging with magnetic resonance imaging would be of clinical value. Such data can be collected only in population based studies as people with normal knees are not usually enrolled into clinical studies or undergo further imaging evaluation. Radiography can show osteophytes, bony outgrowths at the joint margin, and narrowing of the joint space, but it cannot visualise soft tissue pathology.7 In contrast, MRI can visualise various tissues that are clinically relevant and have an important role in regard to structural progression not seen on radiography. MRI can also show incidental findings in otherwise asymptomatic people.8 9 In the knee, MRI visualises most components of the joint, including articular cartilage, menisci, intra-articular ligaments, synovium, bone marrow, subchondral cysts, and other periarticular and intra-articular lesions that are not detectable by radiography.10We used MRI to evaluate the presence of structural changes in knees that were free from radiographic tibiofemoral osteoarthritis. We focused on the tibiofemoral joint, which includes numerous bony and soft tissue structures that can be evaluated by MRI. We evaluated the prevalence of cartilage damage, meniscal lesions, osteophytes, subchondral cysts, bone marrow lesions, ligamentous lesions, attrition, and synovitis on MRI in participants of the Framingham Osteoarthritis Study who had radiographically normal tibiofemoral knee joints. We also assessed whether the prevalence of these features differed according to age, sex, body mass index (BMI), or knee pain.MethodsStudy design and participantsThe Framingham Community cohort was recruited from the Framingham, MA, census tract data for the year 2000 and random digit telephone dialling. All participants were examined between 2002 and 2005. This study cohort is distinct from the Framingham Heart Study and the Framingham Offspring Study cohorts. Participants were not selected on the basis of having knee or other joint problems, and potential participants were not told that knees were a focus of the study.Eligible participants were aged at least 50 and ambulatory (the use of assistive devices such as canes and walker was permitted), with no plans to move out of the area for at least five years to accommodate the possibility of longitudinal follow-up. We excluded those with a history of bilateral total knee replacement, rheumatoid arthritis, dementia, or terminal cancer and those who had contraindications to MRI. Of 2582 people aged 50 or older and living in Framingham who were contacted by random digit dialling, 1830 expressed interest in participating in the study.8 Of those, 39 were lost to contact, 194 were ineligible for the study, and 558 declined to participate. Consequently, 1039 were examined, 993 underwent MRI, and 992 had readable scans (one knee per participant, right knee preferred; left knee if right knee not available (fig 1?).
View larger version:In a new windowDownload as PowerPoint SlideFig 1 Selection process of knees included in present studyKnee radiography and gradingParticipants underwent weight bearing posteroanterior knee radiography with the fixed-flexion protocol.11 One musculoskeletal radiologist, who was blinded to the MRI findings and clinical data, graded radiographs using the Kellgren-Lawrence grading system (intraobserver ? 0.83).12 13 Because we wanted to focus on “normal” tibiofemoral knee joints (Kellgren-Lawrence grade 0), we excluded 253 participants with radiographic tibiofemoral osteoarthritis (Kellgren-Lawrence grade 2 or above), doubtful or equivocal findings of radiographic evidence of tibiofemoral osteoarthritis (Kellgren-Lawrence grade 1), or missing radiographs or radiographic readings. Finally, we excluded 30 participants because of unreadable or poor quality MRIs. This resulted in 710 radiographically “normal” tibiofemoral knee joints being included in the final sample for analysis (fig 1?).MRI grading of osteoarthritis featuresMRI was done with a 1.5 Tesla scanner (Siemens Medical Systems, Erlangen, Germany) with a phased array knee coil. Images from four pulse sequences were used in the assessment of osteoarthritis features: axial, sagittal and coronal fat saturated, proton density weighted, turbo spin echo images (repetition time 3610 msec; echo time 40 msec; slice thickness 3.5 mm; interslice gap 0 mm; echo train length 7; field of view 140 mm × 140mm; matrix 256 × 256) and sagittal T1 weighted spin echo images without fat saturation (repetition time 475 msec; echo time 24 msec; slice thickness 3.5 mm; interslice gap 0 mm; field of view 140 mm×140 mm; matrix 256×256).MRI scans were read by two trained and experienced musculoskeletal radiologists (who did not read the radiographs) using a standardised and validated method called the whole organ magnetic resonance imaging score (WORMS).14 They recorded the presence or absence of the specific features (described below) related to osteoarthritis that were included in our assessment of the tibiofemoral joint (that is, tibial plateaus and the central weight bearing and posterior portions of femoral condyles). In the WORMS system, the tibiofemoral joint is subdivided into 10 different subregions for scoring of each feature. Readings from all subregions were amalgamated within the knee.14 Agreement between observers (? statistic) for the detection of the MRI features was as follows: cartilage damage 0.89; meniscal lesions 0.71; osteophytes 0.73; ligamentous lesions 0.49; bone marrow lesions 0.85; subchondral cysts 0.57; and synovitis 0.63. The relatively low value of ? for ligamentous lesions was because few knees had ligamentous lesions in the reliability sample.Cartilage damage was considered present if there was a small focal loss less than 1 cm in greatest width or areas of diffuse partial or full thickness loss (WORMS grade =2). In this study we did not consider intrachondral signal alterations (WORMS grade 1), which are thought to occur before cartilage damage develops14 but are of unknown clinical importance, to represent cartilage damage.Meniscal lesions (WORMS grade =1) included displaced or non-displaced meniscal tears or evidence of previous surgery (including repair and partial or complete resection) and complete maceration or destruction (that is, loss of normal contour and signal homogeneity within the meniscus) within the anterior and posterior horns and the body of the medial and lateral menisci.14Osteophytes were considered present if there were bony projections that form along different margins of the tibiofemoral joint of the knee (WORMS grade =2). Tiny bony spurs that were equivocal on visual evaluation (that is, “lipping,” WORMS grade =1) were not considered as osteophytes.Ligamentous abnormalities were defined as the presence of a completely torn anterior or posterior cruciate ligament, or a torn or thickened medial or lateral collateral ligament (WORMS grade =1).Bone marrow lesions—Subchondral bone marrow lesions, also known as “bone marrow edema-like lesions,”15 were considered present if there are non-cystic subchondral areas of ill defined high signal on proton density weighted MR images with fat signal suppression (WORMS grade =1).Subchondral cysts were identified as areas of markedly increased signal intensity in the subarticular bone with sharply defined rounded margins and no evidence of internal marrow tissue or trabecular bone on the fat saturated proton density weighted images (WORMS grade =1).Synovitis was considered present if the synovial cavity was distended and filled with fluid (high signal intensity on fat saturated proton density weighted images), representing synovial thickening and joint effusion (WORMS grade =1).14Attrition—Flattening or depression of the articular surfaces of the tibia or femur was termed bone attrition, and any degree of deviation from the normal bony contour was considered abnormal (WORMS grade =1).Additional analysis with a more stringent definition of “abnormality”Currently there is no concrete definition of what is “abnormal” in terms of MRI findings in the knee, and the use of different cut off points for the definition of “abnormality” might produce different results. We also examined a more stringent definition of lesions detected by MRI, which included cartilage damage and osteophytes=WORMS grade =3; all other lesions=grade =2.Assessment of weight, height, and pain We measured the participants’ weight when they were not wearing shoes with the use of a balance beam scale and measured height with a stadiometer. At the clinic visit all participants were asked about knee symptoms with the following question: “In the past month, have you had any pain, aching, or stiffness in your knee?” (for this study, we focused on pain in the knee with MRI reading). Additionally, we assessed knee pain in three more ways. Participants responded to the questions, “Did you have knee pain lasting at least a month in the past year?” and “Do you have knee pain on most days?” A positive response to these questions was considered to indicate the presence of knee pain. Each participant was also asked to fill out the Western Ontario McMaster University arthritis index (WOMAC) questionnaire, and any score =1 in the pain subscale in the knee was considered to indicate the presence of knee pain. For WOMAC pain, we restricted our analysis to participants who had Kellgren-Lawrence grade 0 knees bilaterally as the WOMAC questionnaire was person based and not knee based.Statistical analysisWe calculated the prevalence of the aforementioned osteoarthritis features on MRI and stratified the data according to sex, age group (sixth decade, seventh decade, and older), BMI (<25, =25-<30, =30), and the presence of pain. We used ?2 tests to assess the presence of significant differences between men and women, and among different age and BMI groups. For cartilage and bone marrow lesions, results were stratified according to the medial and lateral tibiofemoral compartments of the knee. All statistical analyses were performed with SAS for Windows, version 9.1. Results were considered to be significant when a two tailed P<0.05.ResultsCharacteristics of study sampleOf the 710 participants, 393 (55%) were women, 660 (93%) were white, and 206 (29%) had painful knees. The mean age was 62.3 (range 51-89), and the mean BMI was 27.9 (range 16.6-50.6) (table 1?).View this table:View PopupView InlineTable 1 Characteristics of participants without knee abnormalities. Figures are numbers (percentage) unless stated otherwisePrevalence of bony and soft tissue abnormalities on MRI with standard definitionOverall, 631 (89%) knees had at least one type of abnormality (fig 2?, table 2?). The three most common findings were osteophytes, cartilage damage, and bone marrow lesions. In the location specific analysis, cartilage damage was more prevalent in the medial tibiofemoral compartment (33% (95% confidence interval 30% to 37%), 235/710) than in the lateral tibiofemoral compartment (20% (17% to 23%), 141/710). Likewise, there were more bone marrow lesions in the medial (19% (16% to 22%), 133/710) than in the lateral tibiofemoral compartment (12% (10% to 16%), 87/710).
View larger version:In a new windowDownload as PowerPoint SlideFig 2 Knee with multiple abnormalities on MRI indicating early stage osteoarthritis despite lack of radiographic osteoarthritis. A: coronal fat suppressed proton density weighted image shows several features of early OA detectable only by MRI. White arrowhead shows focal full thickness cartilage defect at central weight bearing part of medial femur. In addition there is adjacent subchondral bone marrow lesion presenting as area of ill defined hyperintensity (arrows). Black arrowheads show meniscal extrusion at medial joint line causing bulging of neighbouring medial collateral ligament (no arrow). B: sagittal proton density weighted image shows isolated degenerative horizontal oblique tear of posterior horn of medial meniscus extending to undersurface of meniscus adjacent to posterior tibial surface (arrows). No associated cartilage damage or subchondral bony alterations are seenView this table:View PopupView InlineTable 2 Prevalence of MRI features (standard definition*) stratified by sex, pain status, and BMI. Figures are numbers (percentage) of participantsTable 2 summarises the prevalence of each MRI feature overall and in men and women?. The prevalence of meniscal lesions was significantly higher in men than in women (110/317 (35%) v 57/393 (15%); P<0.001). No other features were significantly different between men and women. There were no significant differences in the prevalence of any of the features between BMI groups (table 2). The prevalence of all features was within about 7% among all BMI groups.Older age groups had more abnormalities of all types. Of the participants in their sixth decade, 86% (271/316) had features of osteoarthritis. The rate increased to 91% (227/249) in the seventh decade and 92% (133/145) in the oldest age group. Specific types of abnormalities (cartilage damage, meniscal lesions, osteophytes, subchondral cysts) also increased with each decade (table 3? and fig 3?). The prevalence of ligamentous lesions, bone marrow lesions, attrition, and synovial thickening and joint effusion was also higher in older age groups, but the differences between groups were not significant.View this table:View PopupView InlineTable 3 Prevalence of MRI features (standard definition*) stratified by age group. Figures are numbers (percentage) of participants
View larger version:In a new windowDownload as PowerPoint SlideFig 3 Prevalence of osteoarthritis features on MRI in knees without radiographic osteoarthritis stratified by age group with standard and more stringent definitions of MRI abnormalitiesThe prevalence of attrition (38% v 30%; P=0.04), bone marrow lesions (59% v 50%; P=0.03), and subchondral cysts (31% v 23%; P=0.04) was higher in participants with painful knees than those without pain (table 2). The prevalences for the other features were within about 4% of one another among painful and painless knees with no significant differences (table 2). Indeed, the prevalence of at least one type of MRI detected pathology (“any abnormality”) was high in both painful (91%) and painless (88%) knees (table 2?). Regardless of the definition of pain used, MRI detected abnormalities were highly prevalent in people with (90-97%) and without (86-88%) knee pain. While the prevalence of MRI abnormalities was not significantly different in those with versus those without knee pain for most definitions of pain we tested, the prevalence of “any MRI abnormality” was higher in those with WOMAC pain compared with those without pain (P=0.002). Even so, the prevalence of any MRI abnormality was as high as 86% in those without WOMAC pain.Prevalence of bony and soft tissue abnormalities on MRI with more stringent definitionWhen we used the more stringent definition of MRI abnormality, overall the prevalence of MRI detected lesions dropped as expected (table 4?), to 14% for osteophytes, 44% for cartilage damage, 16% for bone marrow lesions, 4% for synovitis, 10% for attrition, 5% for subchondral cysts, 8% for meniscal lesions, and 2% for ligamentous lesions. The prevalence of any abnormality, however, remained high (53%, 373/710). Except for bone attrition, painful knees did not differ from those without pain in terms of the prevalence of specific features (table 4?). Regardless of the definition of pain used, any abnormality was present in 57-70% of participants with pain and about half of those without pain (table 5?). There were significant differences between groups with and without pain in three out of four definitions of pain, and the largest difference was seen with WOMAC pain (15%, P<0.001). Prevalence of “any abnormality” in those without WOMAC pain, however, was still high (48%).View this table:View PopupView InlineTable 4 Prevalence of MRI features (more stringent definition*) stratified by sex, pain status, and BMI. Figures are numbers (percentage) of participantsView this table:View PopupView InlineTable 5 Prevalence of “any abnormality” on MRI stratified by pain status with standard and more stringent definitions of pain. Figures are numbers (percentage) of participantsDiscussionWe found that MRI detected features of osteoarthritis are highly prevalent in the tibiofemoral joint of knees that did not have any radiographic features of osteoarthritis in participants both with and without knee pain. Nearly 90% of our participants had at least one feature of osteoarthritis on MRI. Osteophytes were the most common, followed by cartilage damage and bone marrow lesions. In general, the older the age group, the higher the prevalence of features of osteoarthritis, although differences among age groups were not significant for synovitis and effusion and of borderline significance for ligamentous lesions and bone marrow lesions. Only meniscal lesions were more prevalent in men than women. No significant differences were observed for any type of lesions by BMI.Strengths and limitationsThis population based study documented the high prevalence of MRI features suggestive of knee osteoarthritis in people without radiographic osteoarthritis. We included only knees that were definitely lacking any radiographic features that could indicate the presence of osteoarthritic changes (Kellgren-Lawrence grade 0) to ensure our analysis is specific. Although Kellgren-Lawrence grade 1 knees also do not qualify for having radiographic osteoarthritis, a “doubtful” bony abnormality is present and one could argue such equivocal findings are difficult to interpret.Limitations Our sample was primarily (although not exclusively) white, reflecting the population of Framingham, MA. The number of people from other racial or ethnic groups was too small for comparisons. Our prevalence estimates cannot be generalised to adults younger than 50. In particular, meniscal lesions in young active otherwise healthy adults are more likely to be caused by trauma than the degenerative process seen in middle aged and older people. We had no arthroscopic correlation of our MRI findings. Ideally, intra-articular pathology (that is, cartilage, meniscus, and ligaments) should be confirmed by direct visualisation during arthroscopy. Arthroscopy, however, is neither feasible nor ethical in large scale population based studies. Furthermore, arthroscopy cannot visualise some of the MRI findings that are indicative of the osteoarthritis disease process such as subchondral bone marrow lesions. Nearly all the knees in our sample were right knees (with only five left knees). A comparison of 99 people with both right and left knee MRIs in this sample, however, showed no difference in findings, and which knee is studied is therefore unlikely to affect our overall outcome. We did not include the evaluation of radiographic patellofemoral joint pathology in this study because we used the posteroanterior radiograph to classify the tibiofemoral joint of the knee using Kellgren-Lawrence grading. We dealt with this fact by including only subregions of the knee that correspond to the tibiofemoral joint for MRI analysis.Because we focused on knees with clearly normal radiographic appearance (Kellgren-Lawrence grade 0), we excluded Kellgren-Lawrence grade 1 knees. One might argue that such knees are also without radiographic osteoarthritis and warrant inclusion in our analysis. Inclusion of the 39 Kellgren-Lawrence grade 1 knees in our sample (total 749 knees) did not alter the demographic characteristics of the participants or analytical results for all aspects of the study. There are many ways to define pain, and it is not possible to include all different pain assessment tools available to date in a single study. We selected the WOMAC pain subscale because it has been validated and is widely used.16 17Our results raise additional questions. More detailed analysis evaluating the factors that could contribute to the differences seen in men and women and the osteoarthritis features in the different age groups would be of interest. Also, comparison of the prevalence of these findings in those with and without radiographic osteoarthritis would tackle the question of whether osteoarthritis is an inevitable consequence of ageing.Comparison with previous studiesOf our findings, the most notable is that 74% of the knees had osteophytes. As a bony abnormality should be clearly visible on radiograph, we did not expect the prevalence to be this high. Presumably, because the MRI assessment used three imaging planes, it could detect osteophytes that were hidden by the overlapping femur or tibia on posteroanterior view radiographs. This is a substantial problem as the presence of definite osteophytes defines the diagnosis of radiographic osteoarthritis.12 Thus far, epidemiological or clinical studies of knee osteoarthritis depend largely on the radiographic definition of osteoarthritis.18 19 As radiography fails to detect such a large proportion of osteophytes, there could be misclassification of a large number of potentially eligible people in knee osteoarthritis studies and underestimation of the true prevalence of this condition.20Although cartilage itself is aneural and is unlikely to be a direct cause of knee pain, cartilage damage is associated with change in bone marrow lesions,21 high BMI, meniscal damage, and synovitis or effusion.22 Cartilage thickness has traditionally been assessed by its surrogate marker—the radiographic width of the joint space of the tibiofemoral joint. Narrowing of the joint space, however, can result not only from cartilage damage but also from meniscal lesions.23 It has been shown that radiography is less sensitive than MRI for detection of cartilage loss.7 Thus, it is not surprising to find a high prevalence of cartilage damage on MRI in the knees of middle aged and older people without radiographic joint space narrowing.The presence and extent of bone marrow lesions and synovial thickening/effusion can be appreciated only on MRI. These lesions have been associated with pain in knees with osteoarthritis.24 25 Furthermore, in people at high risk of developing osteoarthritis, bone marrow lesions in asymptomatic knees with no radiographic osteoarthritis at baseline predict development of pain 15 months later.26 We also found an association of bone marrow lesions with knee pain among people without radiographic osteoarthritis.A high prevalence of incidental meniscal findings on MRI in participants of the Framingham Osteoarthritis Study has been reported previously.8 One or more meniscal tears was present in 32% (41/127) of knees with symptoms, 23% (146/548) of knees without symptoms, and 24% (187/775) overall when there was no or equivocal radiographic evidence of osteoarthritis. Although the results were similar to the present study, they are not identical because Englund and colleagues included knees with Kellgren-Lawrence grade 0 and 1,8 whereas we focused on Kellgren-Lawrence grade 0.We saw fewer incidental ligamentous lesions than any other feature. This could be because the semiquantitative scoring system we used only scores a complete tear as a lesion, and partial tears are given a score of zero. Imaging diagnosis of partial ligamentous tears on MRI can be difficult. The role of intra-articular and periarticular ligaments of the knee in predicting structural progression of knee osteoarthritis remains unclear. Disruption of the integrity of these ligaments, however, will probably cause alterations in knee kinematics.A recent systematic review reported that bone marrow lesions and effusion/synovitis were associated with knee pain.27 In our study, however, these lesions were not significantly more prevalent in participants who had knee pain than in those without, with both definitions of MRI abnormality. This discrepancy is probably because the systematic review included only studies involving mostly people with radiographic knee osteoarthritis. Thus, the conclusion of the systematic review is not applicable to the present study.Clinical implicationsOur findings indicate that the prevalence of MRI detected osteoarthritis features increases with age in the absence of radiographic features of osteoarthritis. We have shown that MRI is more sensitive than radiographs to changes in bone and soft tissue that are considered features of osteoarthritis,28 29 Our data showed that the prevalence of these MRI detected features is high irrespective of the knee pain status. When we compared the prevalence of MRI abnormalities in knees in people with and without pain, there were two trends. Firstly, and most importantly, the prevalence of MRI findings was extremely high in those without pain, suggesting that using MRI as a diagnostic test for people with normal knee radiographs in this age group would have poor specificity. Secondly, the prevalence of findings was modestly higher in those with pain than in those without, with the difference sometimes reaching significance. These differences, however, were not particularly informative—for example, the highest prevalence of MRI abnormalities was actually in those with mild pain rather than moderate or severe pain.Thus, MRI features suggestive of osteoarthritis in people without radiographic osteoarthritis are commonly seen in those with or without knee pain, implying that MRI alone is not diagnostically useful to discriminate between people with and without pain in the context of knee osteoarthritis. MRI might still play an important diagnostic role, especially in younger people, in whom other reasons for knee pain should be considered such as inflammatory arthritides, insufficiency fractures, or spontaneous osteonecrosis. Nonetheless, in all likelihood, MRI features of osteoarthritis will be found regardless of the source of the pain. Our study also highlights the limitations of conventional radiography to detect a large number of abnormalities related to osteoarthritis in the knee.20As high BMI is a known risk factor for both incident knee osteoarthritis and for progression of knee osteoarthritis30 31 we expected to see higher prevalence of MRI features in obese people compared with non-obese people. We did not find high BMI to be associated with higher prevalence of MRI features overall compared with low BMI, but rather that these MRI abnormalities were equally highly prevalent in all BMI groups. We speculate that BMI is important for progression of later stages of osteoarthritis, but potentially age is a much more relevant trigger of early stages of osteoarthritis.Although there is thought to be only a modest correlation between clinical symptoms and radiographic tibiofemoral osteoarthritis,32 recent work has highlighted an association between structural osteoarthritis pathology and knee pain.33 34 It is important for the clinical community to recognise that findings that would be interpreted as abnormal and suggestive of disease are in fact present in most knees without any pain, even when different definitions of pain are used. That means that the clinical significance of these MRI findings is questionable. The same message has been reported for radiographic findings in patients with low back pain (similar highly prevalent abnormalities were seen in those without low back pain), and this led to discouraging radiographic evaluations in those with low back pain.35ConclusionsChanges indicative of osteoarthritis are commonly present in the knees of most people aged 50 and over who have no radiographic evidence of tibiofemoral osteoarthritis. Osteophytes, cartilage damage, and bone marrow lesions are especially common among middle aged and older people. These features are common in knees with pain and in those that are painless and can potentially represent pre-radiographic or early stage osteoarthritis. A longitudinal study is needed to determine what proportion of people without radiographic osteoarthritis but with MRI abnormalities subsequently develop radiographic osteoarthritis.What is already known on this topicMRI can detect features suggestive of knee osteoarthritis that cannot be visualised on conventional radiography, which is insensitive to many findingsIn roughly half of people with knee pain, radiography shows no abnormalitiesWhat this study addsChanges indicative of osteoarthritis are commonly present in the knees of most people aged 50 and over who have no radiographic evidence of tibiofemoral osteoarthritisMRI detected findings of osteoarthritis are common in people with and without knee pain, suggesting that the clinical significance of MRI findings in such knees is not clearNotesCite this as: BMJ 2012;345:e5339FootnotesContributors: AG, JN, DH, and DTF conceived and designed the study. AG, JN, FWR, PA, CEM, and DTF collected the data. AG, DH, FWR, ME, TN, and DTF reviewed the literature. AG, JN, DH, FWR, ME, TN, and DTF directed the analyses, which were carried out by JN. All authors participated in the discussion and interpretation of the results. AG and DH organised the writing and wrote the initial drafts. All authors critically revised the manuscript for intellectual content and approved the final versions. AG and DTF are guarantors.Funding: This study was funded by the National Institutes of Health (AG18393 and AR47785) and the Arthritis Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The researchers work independently of their funders.Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: AG is the president of Boston Imaging Core Lab (BICL), LLC, and a consultant to Merck Serono, Stryker, Genzyme, AstraZeneca, and Novartis; FWR a vice president and shareholder of BICL and is a consultant to Merck Serono and National Institute of Health; ME is funded by the Swedish Research Council, the Greta and Johan Kock Foundation, King Gustaf V 80-year Birthday Foundation, and the Faculty of Medicine, Lund University, Sweden; TN is supported by NIAMS AR055127 and the Arthritis Foundation Arthritis Investigator Award.Ethical approval: This study was approved by the institutional review board of Boston University Medical Centre (protocol number H-22674), and written informed consent was obtained from all participants.Data sharing: No additional data available.This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. 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